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      <JournalTitle>Cancer Case Reports</JournalTitle>
      <Volume-Issue>Volume 1; Issue 1</Volume-Issue>
      <ArticleType>Cancer Research</ArticleType>
      <ArticleTitle>A Rare Case of Hemophagocytic Lymphohistiocytosis with Concurrent Extra-Pulmonary Sarcoidosis Presenting as Fever of Unknown Origin</ArticleTitle>
      <Abstract>Hemophagocytic Lymphohistiocytosis (HLH) is a rare syndrome with uncontrolled inflammation due to an ineffective immune response to antigens, leading to multiorgan failure if not treated aggressively (Atteritano et al., 2012). HLH can be genetic or acquired. Primary HLH, which is diagnosed at an early age, is associated with immunodeficiency syndromes (Rosado and Kim, 2013).The acquired form, which can occur at any age, has various etiologies including infections, malignancies or rheumatological diseases (Schram and Berliner, 2015; Sawhney et al., 2001). The Histiocyte Society defines the diagnostic criteria for HLH on the basis of few characteristics including fever, cytopenia, splenomegaly, hyperferritinemia, hypertriglyceridemia, decreased fibrinogen, hemophagocytosis, increased IL-2 receptor alpha and decreased natural killer (NK) function. Sarcoidosis is a chronic granulomatous and multisystem inflammatory disease, which is rarely associated with HLH (Sawhney et al., 2001). The rheumatologic form of secondary HLH is also known as macrophage activation syndrome (MAS). The most common rheumatic diseases associated with HLH are juvenile arthritis and systemic lupus erythematosus (SLE). The clinical course of the disease is very aggressive, with the mortality rates ranging from 8% to 22%, therefore early diagnosis is key to initiation of prompt treatment (Abughanimeh et al., 2018). In order to add our contribution to the available literature on this under recognized association, we report a unique case of a 70 year old female who presented with fever of unknown origin and ultimately was diagnosed with sarcoidosis complicated by HLH during her hospital course.</Abstract>
      <Keywords>Hemophagocytic lymphohistiocytosis,Macrophage activation,Cytokine storm,Immune dysregulation,Phagocytosis</Keywords>
        <Abstract>https://cancercasereports.com/ubijournal-v1copy/journals/abstract.php?article_id=6477&amp;title=A Rare Case of Hemophagocytic Lymphohistiocytosis with Concurrent Extra-Pulmonary Sarcoidosis Presenting as Fever of Unknown Origin</Abstract>
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