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CANCER CASE REPORTS - Volume 1; Issue 2, (2020)

Pages: 1-15

Multidisciplinary Approaches to Minimally Invasive Cancer Treatment Using Colloidal Iodine: Twelve Case Reports in Digestive System

Norimasa Miura, Takehiko Wago, Ryusuke Fujiki

Category: Cancer Research

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Background: Iodine is a substance with a long history of medical application to human bodies. In addition, when targeting a tumor, the microenvironment is essential to improve the efficacy of cancer therapy. We attempted to examine the synergistic effect of colloidal iodine mainly on gastroenterological malignancies using low-dose-chemotherapy, hyperthermotherapy, and/or hyperbaric oxygen therapy.

Materials and Methods: Colloidal iodine was administered to 12 patients with unresectable in stage IV have an outcome that is treated with palliative medicine. who had already been diagnosed with an incurable, intractable advanced neoplasm, including pancreatic cancer, gastric cancer, esophageal cancer, cholangiocarcinoma, colon cancer, and end-stage rectal cancer. The route of administration was oral for 5 patients, intravenous for 7 patients, and topical for 2 patients. The effect was estimated using a change of tumor markers or/and the findings of endoscopy or computed tomography.

Results: By each modality to evaluate the effect, the addition of iodine successfully reduced tumor size and inhibited the progression of complications in all cases, compared with cases in previous studies treated without iodine. We also confirmed that intravenous infusion was a safe route of administration without adverse effects.

Conclusions: In this pilot study, twenty patients with advanced cancer who received treatment with colloidal iodine in nanoparticle status successfully inhibited tumor progression and improved ADL without adverse effects. As a multidisciplinary approach for both the cancer itself and its microenvironment, the complementary use of colloidal iodine may increase the rate of improvement of cancer via a biomodulating mechanism. This formulations may be useful as one of the multidisciplinary therapeutic modalities and we expect outcomes from the further phase of clinical trials.

Keywords: Colloidal Iodine, Cancer, Biomodulation, Multidisciplinary Therapy, Tumor Microenvironment


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