CANCER CASE REPORTS - Volume 1; Issue 1, (2020)

Pages: 1-6

MDA as A Bio-Marker for Benign Prostatic Hyperplasia in Pakistani Population

Maria Arif, Taha Arif, Aadil Omer, Owais Ahmed

Category: Cancer Research

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Abstract:

Background: Serum malondialdehyde (MDA) is a convenient in vivo index of lipid peroxidation. It is a non-invasive biomarker of oxidative stress. Reactive oxygen species (ROS) could activate some specific signaling pathways that contribute to tumor development by regulating cell proliferation, angiogenesis and metastasis processes. Current study was designed to determine MDA levels in Benign Prostatic Hyperplasia (BPH) as compared to normal control. The study was a Cross-sectional analytical study, which was conducted at Department of Urology, Department of Biochemistry & Molecular Biology Rawalpindi, National University of Science and Technology, Islamabad over a period of one year. Study included sixty eight samples. MDA levels were determined by ELISA (enzyme linked immuno sorbent assay) technique.
Results: We have compared mean value of MDA in BPH and control group, the difference was statistically significant (p=0.002). Conclusions: MDA may be used as bio-marker to determine progression of BPH. Moreover, it is required that additional studies should be carried out to find the pathway involved serum MDA in BPH.

Keywords: Benign prostatic hyperplasia (BPH); Malondialdehyde (MDA); Gleason scoring

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DOI URL: http://dx.doi.org/10.47733/GJCCR.2020.1107